In vitro pharmacokinetic studies

In vivo pharmacokinetic studies

              ● Test article formulation

              ● Test article analysis

              ● Solvent screening

              ● Analytical method development

              ● Measurement of drug concentrations in plasma

              ● Caco-2 drug transport

              ● P-gp drug transport

              ● Plasma protein binding

              ● Cytochrome P450 inhibition and induction

              ● Hepatic microsomal enzyme stability

              ● Plasma/whole blood stability

              ● Bioavailability studies in various species

              ● Preclinical bioequivalence studies

              ● Single or multiple-dose PK studies

              ● Dose escalation experiments

              ● Tissue distribution in vivo

              ● Excretion and mass balance studies

              ● Tissue distribution in rodents